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August 5, 2015 

Pennsylvania drugmaker Zynerba Pharmaceuticals ($ZYNE) is making its way to Wall Street with some cannabis-derived treatments for central nervous system disorders, raising $42 million in an IPO.

The company priced 3 million shares at $14 each, the middle of its range, and set aside another 450,000 shares for its underwriters to line up for as much as $51.8 million in total.

With the proceeds, Zynerba will press forward with a pair of early-stage transdermal patches that mete out cannabinoid chemicals to treat a host of CNS ailments. ZYN002, slated to enter clinical trials in the second half, has shown promise in refractory epilepsy, Fragile X syndrome and osteoarthritis pain, the company said. And ZYN001, in line for Phase I next year, targets fibromyalgia and peripheral neuropathic pain.

The promise of cannabis-derived pharmaceuticals has drawn a slew of companies to the field over the past few years, including GW Pharmaceuticals ($GWPH) and Insys Therapeutics ($INSY). But unlike its further-along competitors, Zynerba's treatments are synthetically manufactured and don't require growing and maintaining cannabis plants, which the company bills as a practical and financial advantage. Furthermore, Zynerba's transdermal therapies get their active ingredients straight into the circulatory system, avoiding the bioavailability issues that can plague oral treatments that must first navigate the stomach and liver.

Zynerba is led by CEO Armando Anido, appointed in 2014 after stints at the helm of Auxilium Pharmaceuticals, acquired by Endo Pharmaceutical ($ENDP) for about $2.6 billion, and NuPathe, which went to Teva ($TEVA) for $144 million last year.

Meanwhile, biotech's ongoing IPO boom has continued unabated into the second half of 2015, marked by a record debut for Patrick Soon-Shiong's NantKwest ($NK). And the queue of drug developers angling to go public remains full, as Zynerba joins a group including gene therapy outfit Gensight Biologics and food allergy biotech Aimmune Therapeutics.

The original post can be seen here.

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Economy of Scale - The cost advantage that arises with increased output of a product. Economies of scale arise because of the inverse relationship between the quantity produced and per-unit fixed costs; i.e. the greater the quantity of a good produced, the lower the per-unit fixed cost because these costs are shared over a larger number of goods. Economies of scale may also reduce variable costs per unit because of operational efficiencies and synergies. Economies of scale can be classified into two main types: Internal – arising from within the company; and External – arising from extraneous factors such as industry size. – “Investopedia”

I am constantly asked “how can I expand my cannabis business across state borders?”  I am then forced to explain how the U.S. system of federalism works.  Even though medical and/or recreational use of cannabis may be legal in your state, it is not legal on a federal level.  Why?  This boils down to the same issue concerning banking for the cannabis industry – the Schedule I Classification of cannabis makes its possession, use, cultivation and/or sale a federally illegal activity.  Then logically following, from a federal perspective, the proceeds of activities involving Schedule I “drugs” are the proceeds of illegal activities. 

Constitutional law then forces us to examine two important issues – (i) Preemption and (ii) Interstate Commerce.  The “Supremacy Clause” states that state laws which conflict or contradict federal law, are null and void.  Federal law is therefore the “law of the land”.  So in essence, all state legalization of cannabis, in any category, will not be “legally” recognized by the federal government with respect to law enforcement.  These real battles are being fought every day in states that have legalized cannabis use.  For the moment, the federal government seems to content to allow the great cannabis experimentation to continue, while occasionally issuing “safe-harbor” guidance that is quickly disregarded.

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How to Find Your Breakthrough Idea & Brand YOU in the Cannabis Industry

These days it’s harder than ever to break through, especially in an industry whose bandwagon is quickly filling up like the SF cable car. There is so much noise, everyone is screaming and trying to get their message across, staking their claim in the green rush. It’s great in the sense that without gatekeepers more people are able to express their ideas, but the downside is that it’s harder than ever to actually be heard. I, personally, like when the best ideas win.

So, how do you find your breakthrough idea? Many people know generally where they want to go, but it takes more than that. There are five major ways to get to your “idea destination”. You don’t even have to do all five. Pick one and execute it well. That’s enough to make your name in the cannabis industry. 

Start with a niche strategy then expand strategically outward

You can’t just say I’m going to be the expert in something. In that category, you will compete with the entire world. You have to narrow it down. The secret to that however, is that you don’t want to be pigeonholed doing that. You need to move into new territory from there. It’s all about circling the area around a niche. A good niche is one that you can become the master of, because the big players in the industry only talk about it periodically. Where do you get the seed for finding a niche? Well, solving your own problem is one way. If you are in a situation, others are too. Also, draw from your personal experiences. Notice needs and find a solution. 

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SMITHS FALLS, ON, July 8, 2015 /CNW/ - Tweed Marijuana Inc. ("TMI" or "the Company"), parent company of Tweed Inc. ("Tweed") and Tweed Farms Inc. ("Tweed Farms") is pleased to announce that pursuant to notification received today from Health Canada, licensed producers such as Tweed and Tweed Farms will be eligible to produce and sell cannabis oils pending the necessary inspections and approvals from Health Canada.

Until today the Marihuana for Medical Purposes Regulations (MMPR) only allowed for the sale of dried cannabis flower. With the addition of cannabis oils to the regulatory framework, Tweed will be able to significantly increase its product offering to provide a more diverse variety for practitioners and patients.

"This is a natural sign of progression in the industry and a big step forward for patients seeking access to a variety of diverse products," said Mark Zekulin, President of Tweed. "Tweed has the largest growing facilities in the country, and is ready to move expeditiously to offer its customers a diverse line of oil extracts."

Tagged in: Cannabis Company Tweed
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Transaction Unites Canada’s Two Strongest Cannabis Brands, and Establishes World’s Largest Publicly-Traded Cannabis Producer

June 24, 2015 – Toronto and Smiths Falls, Canada – Tweed Marijuana Inc. (“TMI” or “Tweed”) (TSXV: TWD), operator of licensed cannabis producers Tweed Inc. and Tweed Farms Inc., and Bedrocan Cannabis Corp. (“Bedrocan Canada”) (TSXV: BED) are pleased to announce that they have entered into a definitive arrangement agreement, pursuant to which TMI will acquire all of the issued and outstanding securities of Bedrocan Canada. TMI will be renamed at its annual meeting of shareholders to reflect its evolution as a multi-brand holding company. This acquisition marks the beginning of the structured evolution of the Canadian cannabis sector, and it is intended that TMI’s portfolio of technologies, brands and geographies will continue to expand.

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